And Alzheimer’s patients are particularly sensitive to vomiting because it can lead to other problems such as pneumonia, massive gastrointestinal bleeding, esophageal rupture and even death, the group said. Patients often stop taking the higher dose because of its strong side effects such as vomiting. The group also said the higher dose does not appear to give any benefits to the patients. The group says that the drug in higher dose compared with the 10-milligrams could pose increased adverse effects such as slowed pulse rate, nausea, vomiting, diarrhea, urinary incontinence, fatigue, dizziness and agitation. The Public Citizen’s Health Research Group called the 23-milligram dose of Aricept “significantly more toxic” than the 10-milligram dose and said it “should be immediately withdrawn from the market.” Aricept which is taken daily, could slow the mental decline, but it does not cure or prevent Alzheimer's. It is prescribed to improve mental function, such as memory, attention and reasoning by increasing a brain chemical. The drug, donepezil, sold under the brand Aricept, is administered in several doses – the highest being 23 milligrams – for patients with moderate to severe Alzheimer’s disease. A specific dose of Alzheimer’s drug should be pulled from the market because it poses a risk to patients, according to a consumer group.
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